Membranous nephropathy, hydrocarbon exposure and genetic variants of hydrocarbon detoxification

Serum laminin, hydrocarbon exposure, and glomerular damage.

It has been postulated that occupational exposure to hydrocarbons may damage the kidney and lead to glomerulonephritis and chronic renal failure. As laminin is a ubiquitous basement membrane component that seems to play a central part in the structure and function of basement membranes and as the normal renal filtration process is highly dependent on an intact glomerular basement membrane, the ...

Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

In the inbred C57BL/6N mouse, aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons increases rapidly in the neonatal period; this response to these pharmacological, exogenous compounds does not appear in the DBA/2N, NZW/BLN, or NZB/BLN strains. The development of the constitutive hydroxylase activity in the neonatal period is the same in all four strains. Small differences in pH op...

Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.

The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. To investigate the hypothesis that the genetic variants in the AHR gene might be a causal genetic susceptibility to PAH-DNA adduct formation and glioma risk, we conducted a case-control study of 384 glioma cases and 384 cancer-free controls to explore the association between s...

Hydrocarbon Toxicity: A Review of Literature and Case Series

Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy?